Interactions between α-synuclein proteins and lipid bilayer membranes

报告题目：Interactions between α-synuclein proteins and lipid bilayer membranes

报告人：叶方富 教授， 中科院物理所

报告时间：2019年1月29日星期二 上午10点

报告地点：物理科技楼 247 

报告摘要：α-synuclein proteins are closely related to both Parkinson’s disease and Alzheimer’s disease. We investigate interactions between α-synuclein and different lipid bilayers by using Dissipative Particle Dynamics simulations, aiming to understand how the compositions of the lipid bilayers may influence these interactions. We find, α-synucleins on bilayers composed of 922 DOPC and 230 DOPS lipids take a variety of conformations. For lipid bilayers composed of DPPC, POPS, POPE and lysoPC (or lysoPS, or lysoPE) lipids, lysolipids facilitate the adsorption of α-synucleins to the lipid bilayers. We also investigate the biophysical properties of ethanolamine plasmalogens (pl-PEs) and choline plasmalogens (pl-PCs) by all-atom molecular dynamics simulations, and find that the vinyl-ether bond increases the order and membrane thickness of pl-PEs (compared with SAPE lipids) while the choline group decreases the membrane thickness of pl-PCs (compared with pl-PEs).

报告人简介：Professor Fangfu Ye received his B.S. in astronomy from Peking University in 1999 and his Ph.D. in Physics from the University of Pennsylvania in 2007. He was a postdoctoral fellow at the Liquid Crystal Institute of Kent State University (2007-2009), and a postdoctoral research associate at the University of Illinois at Urbana-Champaign (2009-2011) and the Georgia Institute of Technology (2011-2013). He joined the Institute of Physics of Chinese Academy of Sciences in 2013. His current research interests focus on protein-membrane interactions and collective behaviors of cells and active matter.