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Design of Functional Micelles for Drug Delivery

报告题目:Design of Functional Micelles for Drug Delivery

报 告 人:Prof. Martina StenzelUniversity of New South Wales

报告时间:2016年923日(星期五)下午 3:30

报告地点:独墅湖校区907号楼1445室

 

Micelles and vesicles have long been proposed as carriers for low molecular weight molecules including drugs. Latest developments in polymer synthesis allow the design of well-controlled architectures. In particular living radical polymerization such as RAFT polymerization enable the high throughput of large polymer libraries.1 However, synthetic polymers alone cannot provide the specificity and bioactivity of nature’s building blocks such as carbohydrates and protein. In this presentation, we discuss all the aspects that determine the interaction of micelles with mammalian cells including parameters such as the shape of the nanoparticles and the surface chemistry. We will focus in particular on materials that were created based on glycopolymers or albumin as the outer shell.

  

Martina Stenzel

Martina Stenzel studied chemistry at the University of Bayreuth, Germany, before completing her PhD in 1999 at the Institute of Applied Macromolecular Chemistry, University of Stuttgart, Germany. She started as a postdoctoral fellow at UNSW in 1999 and is now a full Professor in the school of chemistry as well as co-director of the Centre for Advanced Macromolecular Design (CAMD)

Her research interest is focused on the synthesis of functional nanoparticles for drug delivery applications. Martina Stenzel published more than 230 peer reviewed papers mainly on polymer and nanoparticle design.

She is scientific editor of Materials Horizons and serves currently on a range of editorial boards. She received a range of awards including the 2011 Le Fèvre Memorial Prize of the Australian Academy of Science.