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陈高健课题组在Macromolecular Rapid Communcations(IF4.929)上发表研究论文

发布时间:2017-05-03 11:00

Title:Microwave-Assisted Synthesis of Glycopolymer-Functionalized Silver Nanoclusters: Combining the Bioactivity of Sugar with the Fluorescence and Cytotoxicity of Silver

Author: Wei Lu, Wenjuan Ma, Jiawei Lu, Xiao Li, Yun Zhao* and Gaojian Chen*

Abstract:   Copolymers of 2-(methacrylamido)glucopyranose (MAG) and methacrylic acid (MAA) are synthesized by RAFT polymerization and then used as templates to prepare glycopolymer-functionalized Ag nanoclusters (Gly-Ag NCs) through microwave irradiation. Polymers and the resulting nanoclusters are characterized by NMR, GPC, UV-Vis, SEM, TEM, AAS and fluorescence spectroscopy. The bio-activity of the fluorescent Gly-Ag NCs are further examined using GLUT-1 over-expressing cancer cells K562. Gly-Ag NCs show efficient binding ability toward K562 cells and inhibit the cell viability in a dose dependent manner (IC50 = 0.65 μg mL-1), indicating their potential biological applications for both cancer imaging and targeted cancer therapy.